150
+
1,100
+
42
+
97
%
18,400
+
Enrollment At Risk
Despite activating 60 sites across the United States, Germany, and Spain, enrollment progress lagged far behind projections. The study faced a limited pool of eligible adult patients, strict eligibility requirements, and low patient awareness of clinical trial participation.
Recruitment efforts relied heavily on site-driven outreach, placing additional strain on already overburdened research teams. As referral volume remained low and screen failures increased, sites lacked the time and resources to conduct proactive recruitment, further slowing enrollment.
With more than 70% of randomizations remaining and only a couple of months left in the enrollment window, the study had no room to absorb delays—putting timelines, budget, and overall study success at risk.
The Situation (At A Glance)
- Study Status: 14 months behind schedules
- Time Remaining: 5 months
- Enrollment Target: 140 patients
- Enrolled at Intervention: 46 patients
- Geography: United States, Germany, Spain
- Sites: 60 active sites
Severe enrollment risk with no remaining buffer for delays.
ENROLLMENT CHALLENGES
As enrollment progressed, several compounding challenges emerged:
- Limited eligible patient pool
- Strict eligibility and washout requirements
- Low patient awareness
- Site capacity constraints
- Delayed visibility into performance
WHAT DROVE THE RESULTS
- Protocol-Specific Online Screeners
- Registered Nurse Led Second-Line Screening
- Human-Centric Patient Messaging
- Local-Language Engagement
- Real-time Performance Optimization
The Results
84 of 117
Enrolled Patients from
3.55x
Enrollment Growth
33 117
12.73 Month
Recovered on the Timeline
AutoCruitment’s patient recruitment platform supports Sponsors, CRO Partners and Research Sites by decreasing time, risk and cost to bring new therapies to market.